Medications

• September 24, 2026

  What is the evidence for the analgesic effectiveness, safety, and patient/clinician satisfaction of inhaled methoxyflurane compared to placebo or standard care analgesics in patients presenting to the emergency department with acute traumatic pain?

  Lam L, Brouwer HJ, Gupta M, Ker CJ, Jones C, Athar A, Roman C, Mitra B, Brichko L, Luckhoff C, Jennings N, Cameron P. Effectiveness of inhaled methoxyflurane in acute pain in an emergency department - A systematic review of randomized controlled trials. Am J Emerg Med. 2025 Aug;94:37-45. doi: 10.1016/j.ajem.2025.04.021. Epub 2025 Apr 13. PMID: 40273636.
• September 23, 2026

  What is the evidence for oral or intra-articular administration of collagen derivatives in patients with osteoarthritis for joint pain reduction and physical function improvement?

  Liang CW, Cheng HY, Lee YH, Liao CD, Huang SW. Efficacy and safety of collagen derivatives for osteoarthritis: A trial sequential meta-analysis. Osteoarthritis Cartilage. 2024 May;32(5):574-584. doi: 10.1016/j.joca.2023.12.010. Epub 2024 Jan 11. PMID: 38218227.
• September 22, 2026

  What is the evidence for perioperative administration of duloxetine in patients undergoing total knee or hip arthroplasty for postoperative pain management and narcotic consumption reduction?

  Zhong H, Li J, Chen Y, Huang Y, Wen Z, Zhao J. Effect of duloxetine on pain and opioid consumption after total knee and hip arthroplasty: a systematic review and meta-analysis of randomized controlled trials. Int J Clin Pharm. 2024 Feb;46(1):14-25. doi: 10.1007/s11096-023-01593-x. Epub 2023 Jun 9. PMID: 37294475.
• August 5, 2014

  What is the evidence for dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis of the knee?

  Brien, S., et al. (2011). "Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis of the knee." Evid Based Complement Alternat Med 2011: 528403.
• August 5, 2014

  What is the evidence for S-Adenosylmethionine in the treatment of osteoarthritis of the knee?

  Rutjes, A. W., et al. (2009). "S-Adenosylmethionine for osteoarthritis of the knee or hip." Cochrane Database Syst Rev(4): CD007321.
• August 5, 2014

  What is the evidence for avocado-soybean unsaponifiables in the treatment of osteoarthritis of the knee?

  Christensen, R., et al. (2008). "Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials." Osteoarthritis Cartilage 16(4): 399-408.
  
• August 5, 2014

  What is the evidence for collagen derivates (e.g. gelatin) in the treatment of osteoarthritis of the knee?

  Van Vijven, J. P., et al. (2012). "Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: a systematic review." Osteoarthritis Cartilage 20(8): 809-821.
• August 5, 2014

  What is the evidence for glucosamine chondroitin in the treatment of osteoarthritis of the knee?

  Hochberg, M. C. (2010). "Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration." Osteoarthritis Cartilage 18 Suppl 1: S28-31.
• July 25, 2014

  What is the evidence for nutritional supplementation in the treatment of osteoarthritis of the knee?

  Lopez, H. L. (2012). "Nutritional interventions to prevent and treat osteoarthritis. Part II: focus on micronutrients and supportive nutraceuticals." PM R 4(5 Suppl): S155-68.
• July 21, 2014

  What is the evidence for acetaminophen in treating osteoarthritis of the knee?

  Towheed, T., et al. (2006) Acetaminophen for osteoarthritis. Cochrane Database of Systematic Reviews DOI: 10.1002/14651858.CD004257.pub2